Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China.

نویسندگان

  • Rong Zhang
  • Dachuan Lin
  • Edward Wai-Chi Chan
  • Danxia Gu
  • Gong-Xiang Chen
  • Sheng Chen
چکیده

We report the emergence of five carbapenem-resistant K1 hypervirulent Klebsiella pneumoniae (hvKP) strains which caused fatal infections in hospital patients in Zhejiang Province, China, upon entry through surgical wounds. Genotyping results revealed the existence of three genetically related strains which exhibited a new sequence type, ST1797, and revealed that all strains harbored the magA and wcaG virulence genes and a plasmid-borne bla(KPC-2) gene. These findings indicate that K1 hvKP is simultaneously hypervirulent, multidrug resistant, and transmissible.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Draft Genome Sequences of Three Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Isolates from Bacteremia

Hypervirulent Klebsiella pneumoniae strains have been increasingly reported worldwide, and there is emergence of carbapenem resistance among them. Here, we report the genome sequences of three carbapenem-resistant hypervirulent K. pneumoniae isolates isolated from bacteremic patients at a tertiary-care center in South India.

متن کامل

Clinical and microbiological characteristics of Klebsiella pneumoniae liver abscess in East China

BACKGROUND Klebsiella pneumoniae has been the dominant pathogen for liver abscesses in several Asian countries. Although the prevalence of K. pneumoniae liver abscess (KLA) in mainland China is increasing recently, the clinical and microbiological characteristics of KLA in China have not been elucidated. METHODS Clinical and microbiology characteristics of 45 consecutive patients with KLA fro...

متن کامل

Draft Genome Sequence of an NDM-1- and KPC-2-Coproducing Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Isolated from Burn Wound Infections

We report here the draft genome sequence of an NDM-1- and KPC-2-coproducing hypervirulent carbapenem-resistant Klebsiella pneumoniae strain, isolated from a 58-year-old male in the People's Republic of China with a burn injury.

متن کامل

Title : Clinical and microbiological characteristics of Klebsiella 1 pneumoniae liver abscess in China 2 3 Running title : Klebsiella pneumoniae liver abscess in China

26 Background: Klebsiella pneumoniae has been the dominant pathogens for liver 27 abscesses in several Asian countries. Although the prevalence of K. pneumoniae liver 28 abscess (KLA) in mainland China is increasing recently, the clinical and 29 microbiological characteristics of KLA in China have not been elucidated. 30 Methods: Clinical and microbiology characteristics of consecutive 45 patie...

متن کامل

259IgG mAbs against Klebsiella pneumoniae K1-CPS as a possible new therapeutic approach

Background. Klebsiella pneumoniae (Kp) infections with hypervirulent (hvKp) serotypes are common in Asia and emerging in the US. Although these strains are usually sensitive to antibiotics they are highly invasive and can cause life-threatening infections including liver abscesses, pneumonia, meningitis and endophtalmitis in otherwise healthy patients. Also of concern is that ESBL and carbapene...

متن کامل

ذخیره در منابع من

ذخیره در منابع من قبلا به منابع من ذحیره شده

{@ msg_add @}


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 60 1  شماره 

صفحات  -

تاریخ انتشار 2016